| Eli Wallach (Tuco) | Clint Eastwood (Blondie) | Lee Van Cleef (Sentenza/Angel Eyes) |
| Aldo Giuffre (Alcoholic Union Captain) | Luigi Pistilli (Father Pablo Ramirez) | Rada Rassimov (Maria) |
| Enzo Petito (Storekeeper) | Claudio Scarchilli (Bounty Hunter in Ghost Town) | John Bartha (Sheriff) |
| Livio Lorenzon (Baker) | Antonio Casale (Jackson/Bill Carson) | Sandro Scarchilli (Deputy) |
| Benito Stefanelli (Member of Angel Eyes' Gang) | Angelo Novi (Monk) | Antonio Casas (Stevens) |
| Aldo Sambrell (Member of Angel Eyes' Gang) | Al Mulock (One-armed Bounty Hunter) | Sergio Mendizabal (Blonde Bounty Hunter (as Sergio Mendizab) |
| Antonio Molino Rojo (Captain Harper (as Molino Rocho)) | Lorenzo Robledo (Member of Angel Eyes' Gang) | Mario Brega (Cpl. Wallace) |
| Chelo Alonso (Stevens' Wife (non-crédité)) | Roman Ariznavarreta (Bounty Hunter (non-crédité)) | Frank Brana (Bounty Hunter #2) |
| Saturno Cerra (Bounty Hunter (non-crédité)) | Luigi Ciavarro (Member of Angel Eye's Gang (non-crédité)) | William Conroy (Confederate Soldier (non-crédité)) |
| Jesús Guzman (Pardue the Hotel Owner (non-crédité)) | Víctor Israel (Sergeant at Confederate Fort (non-crédité) | Nazzareno Natale (Mexican Bounty Hunter) |
