| Anthony Hopkins (Hannibal Lecter) | Julianne Moore (Clarice Starling) | Gary Oldman (Mason Verger) |
| Ray Liotta (Paul Krendler) | Frankie Faison (Barney) | Giancarlo Giannini (Pazzi) |
| Francesca Neri (Allegra Pazzi) | Zeljko Ivanek (Dr. Cordell Doemling) | Hazelle Goodman (Evelda Drumgo) |
| David Andrews (FBI Agent Pearsall) | Francis Guinan (FBI Director Noonan) | James Opher (DEA Agent Eldridge) |
| Enrico Lo Verso (Gnocco) | Ivano Marescotti (Carlo) | Fabrizio Gifuni (Matteo) |
| Alex Corrado (Piero) | Marco Greco (Tommaso) | Robert Rietty (Sogliato (as Robert Rietti)) |
| Terry Serpico (Officer Bolton) | Boyd Kestner (Special Agent Burke) | Peter Shaw (Special Agent Brigham) |
| Kent Linville (FBI Mail Boy) | Don McManus (Asst. Mayor Benny Holcombe) | Harold Ginn (Larkin Wayne) |
| Ted Koch (BATF Agent Sneed) | William Powell-Blair (FBI Agent (as Wm. Powell Blair II)) | Aaron Craig ('Il Mostro' Detective) |
| Andrea Piedimonte (Agent Benetti) | Ennio Coltorti (Ricci) | Ian Iwataki (Young Boy in Plane) |