| Bill Bailey (The Whale) | Anna Chancellor (Questular Rontok) | Warwick Davis (Marvin) |
| Mos Def (Ford Prefect) | Zooey Deschanel (Trillian) | Su Elliot (Pub Customer (as Su Eliott)) |
| Martin Freeman (Arthur Dent) | Stephen Fry (Narrator/The Guide) | Richard Griffiths (Jeltz) |
| Dominique Jackson (Fook) | Simon Jones (Ghostly Image) | Thomas Lennon (Eddie the Computer) |
| Mark Longhurst (Bulldozer Driver) | Kelly MacDonald (Reporter) | John Malkovich (Humma Kavula) |
| Ian McNeice (Kwaltz (voix)) | Helen Mirren (Deep Thought) | Bill Nighy (Slartibartfast) |
| Steve Pemberton (Mr. Prosser/Additional Vogon Voixs) | Alan Rickman (Marvin) | Sam Rockwell (Zaphod Beeblebrox) |
| Mark Gatiss (Additional Vogon Voixs) | Reece Shearsmith (Additional Vogon Voixs (as The League o) | Jack Stanley (Lunkwill) |
| Mak Wilson (Vogon Interpreter (voix)) | Albie Woodington (Barman) | Mason Ball (Creature Performer) |
| Sarah Bennett (Creature Performer) | Danny Blackner (Creature Performer) | Hayley Burroughs (Creature Performer) |